This drop is largely dictated by the venous side of the circulatory system which holds 75 % of the circulating blood volume.
2.
If the dehydration is profound enough to cause a decrease in the circulating blood volume, tachycardia ( a fast heart rate ) and low blood pressure may be observed.
3.
This, the observed diminished stroke volume ( cardiac output ) is certainly contributory and, in turn, is a reflection of diminished venous return and contracted effective circulating blood volume induced by spaceflight factors.
4.
All nonterminal blood collection without replacement of fluids is limited up to 10 % of total circulating blood volume in healthy, normal, adult animals on a single occasion and collection may be repeated after 3 to 4 weeks.
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